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Navigating the complexities of ADHD medications can be daunting for anyone touched by the disorder—be it a concerned parent, an adult newly diagnosed, or someone simply striving to manage daily life. With ADHD impacting an array of core functions—from attention and impulsivity to executive tasks like planning and prioritizing—understanding the side effects of various ADHD medications isn’t just useful; it’s essential. This comprehensive guide delves into what ADHD medications are, why they are necessary, and the dual-edged sword of their side effects, both physical and psychological. Whether you’re considering medication for the first time or seeking deeper insights into your current regimen, you’re in the right place.

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What Is ADHD Medicine?

ADHD medications are designed to help manage the core symptoms of Attention-Deficit/Hyperactivity Disorder (ADHD), which include inattention, hyperactivity, and impulsivity. These medications do not cure ADHD but improve focus, self-control, and stability by enhancing brain chemistry. 

These statistics highlight the significance of ADHD as a common childhood disorder and the role of medication in its management. 

Prevalence of ADHD

According to the Centers for Disease Control and Prevention (CDC), as of 2016, approximately 6.1 million children in the United States were diagnosed with ADHD. This represents about 9.4% of children aged 2-17 years.

Medication Rates 

Among children with an ADHD diagnosis, about 62% were taking ADHD medication. This translates to about 5% of all children in the U.S.

Trends Over Time 

The percentage of children aged 2-5 years receiving ADHD medication increased from 0.8% in 2007 to 1.0% in 2016. Among children aged 6-11, about 9.6% were on ADHD medication in 2011, showing a rise from previous years.

Gender and Medication 

Boys are more likely than girls to be diagnosed with ADHD and subsequently more likely to be prescribed medication. Approximately 13.2% of boys compared to 5.6% of girls are diagnosed with ADHD.

Impact of Treatment 

Studies suggest that among those treated for ADHD, approximately 70-80% of children show improvement in symptoms with ADHD medications as part of their treatment plan.

Why Do People Need ADHD Medication?

Medications are used to increase the brain’s ability to engage in “executive functions,” including organizing, planning, and sustaining attention. For many individuals with ADHD, medication is a part of a comprehensive treatment plan that includes behavioral therapy, counseling, and practical support in educational and work environments.

How Does ADHD Medicine Work?

ADHD medications typically target neurotransmitters in the brain, enhancing the function of chemicals like dopamine and norepinephrine. These chemicals are critical for transmitting signals between neurons, helping improve attention span and reduce impulsivity and hyperactivity.

Different Types of ADHD Medications


Stimulants are the most widely used medications for treating ADHD. They are known for their quick onset and effectiveness in improving concentration and reducing impulsivity and hyperactivity.

💊Methylphenidate: Commonly known under brand names such as Ritalin, Concerta, and Methylin. Methylphenidate is available in various forms, including immediate-release, sustained-release, and extended-release.

💊Amphetamines: This category includes dextroamphetamine (Dexedrine), amphetamine/dextroamphetamine (Adderall), and lisdexamfetamine (Vyvanse). These medications are also available in various formulations to suit different duration needs throughout the day.

There are two forms of stimulants:

  • Immediate-release (short-acting) formulas last for about 3–6 hours.
  • Extended-release (intermediate-acting or long-acting) formulas stay in the body for up to 12 hours. Longer-acting ADHD medications may result in fewer “ups and downs” during the day. They can be helpful for people who have a long school day and need the medicine to stay focused for homework or after-school activities.


Non-stimulants are used for patients who may not respond well to stimulants or who experience significant side effects. They generally have a slower onset of action but are effective in improving attention and reducing impulsivity.

💊Atomoxetine: Marketed under the brand name Strattera, atomoxetine is a selective norepinephrine reuptake inhibitor and does not have the same abuse potential as stimulants.

💊Guanfacine: Available as Intuniv (extended-release) and Tenex (immediate-release), guanfacine is often used in treating ADHD and works by affecting receptors in the brain that improve attention and reduce impulsivity.

💊Clonidine: Known commercially as Kapvay (extended-release) and Catapres (immediate-release), clonidine is also used primarily for its ability to enhance attention and manage behavioral symptoms.


While not primarily indicated for ADHD, certain antidepressants are used off-label to manage ADHD symptoms, especially in patients with co-existing conditions like anxiety or depression.

💊Bupropion: Sold under the brand name Wellbutrin among others, bupropion is often used off-label for ADHD. It affects neurotransmitters dopamine and norepinephrine but is not classified as a stimulant.

💊Venlafaxine: Known as Effexor, venlafaxine is a serotonin-norepinephrine reuptake inhibitor (SNRI) that can also help manage ADHD symptoms, particularly in adults.

💊Trazodone: Occasionally used off-label for ADHD, especially when patients also suffer from insomnia or anxiety.

Commonly Prescribed Medications

Methylphenidate-based Medications

Prevalence: Methylphenidate, particularly under brand names like Ritalin and Concerta, is one of the most commonly prescribed stimulant medications for ADHD. It accounts for about 30% of ADHD medication prescriptions in the United States.

Usage: Studies suggest that methylphenidate is effective in improving symptoms of ADHD in about 70-80% of children who take it as part of their treatment regimen.

Amphetamine-based Medications

Prevalence: Amphetamine formulations, including Adderall and Vyvanse, represent a significant portion of ADHD treatments, with Adderall being one of the most commonly recognized names. They account for about 39% of ADHD medication prescriptions.

Efficacy: Clinical trials and user reports indicate that amphetamine-based medications can improve ADHD symptoms in approximately 70-80% of the patients, similar to methylphenidate.

Non-stimulant Medications

Usage: Non-stimulant medications, such as atomoxetine (Strattera), are less commonly prescribed than stimulants but are crucial alternatives for patients who do not tolerate stimulants well or who have certain co-existing conditions. Atomoxetine itself accounts for about 5-7% of ADHD medication prescriptions.

Efficacy: Atomoxetine shows a slightly lower response rate compared to stimulants, with about 65% of patients experiencing significant improvement in ADHD symptoms.

Side Effects of ADHD Medication

A list of the side effects of ADHD medication

Physical Side Effects

❤️Heart Rate and Blood Pressure

Stimulant medications for ADHD, such as methylphenidate and amphetamines, can lead to increased heart rate and blood pressure. This effect can be particularly challenging for adult professionals in high-stress jobs or students during exams, where anxiety may already be heightened, potentially exacerbating cardiovascular stress.

These cardiovascular effects are identified in approximately 10% to 20% of children treated with stimulants.

🤯Headaches and Dizziness

Headaches and dizziness are common side effects that can significantly disrupt daily activities for users of both stimulant and non-stimulant medications. For example, a student might find it difficult to concentrate during lectures or exams, while an adult might struggle with these symptoms during important work meetings or while driving.

Headaches are reported as a side effect by about 19% of patients using stimulant medications, making it one of the more common physical side effects. Dizziness is less commonly reported but still affects a significant minority of patients.

🥴Gastrointestinal Issues

Many patients experience stomach pains, nausea, and vomiting, especially when beginning a new medication or after a dosage increase. This can be particularly distressing for a child at school who may need to visit the school nurse or come home, or an adult at work who might find themselves unable to attend crucial meetings or complete tasks effectively.

Gastrointestinal problems such as stomach pain, nausea, and decreased appetite are very common, occurring in about 25% to 30% of individuals taking ADHD medications, particularly when treatment is initiated or doses are changed.

👄Dry Mouth

Dry mouth, although seemingly minor, can affect comfort and oral health. 

A student may find it uncomfortable to participate in class discussions or presentations, and adults may struggle during long meetings or presentations where speaking is required.

Dry mouth is reported by about 10% to 15% of patients treated with both stimulant and non-stimulant ADHD medications, according to patient surveys and clinical trials.

Psychological Side Effects

💨Mood Changes

Mood swings, irritability, and depression from stimulant medications can affect emotional regulation. 

A student may have trouble maintaining peer relationships or behave disruptively in class, while adults may find these mood swings impacting their professional relationships, personal relationships and overall job performance.

💤Sleep Problems

The stimulating effects of certain ADHD medications can lead to significant sleep disturbances. 

For students, this might mean difficulty sleeping the night before important tests or activities, impacting academic performance. Adults with adhd may experience challenges in managing their professional responsibilities due to fatigue or lack of restful sleep.

Difficulty sleeping is one of the most commonly reported side effects of stimulant medications, affecting around 25% to 50% of individuals taking these drugs. The impact is most pronounced for those taking medications later in the day.

😬Nervousness or Anxiety

The onset of treatment with stimulant medications can induce feelings of nervousness or anxiety, which might be particularly problematic during public speaking engagements or exams for students, and critical business presentations or negotiations for adults.

Long-Term Effects

Potential Risks and Benefits

While ADHD medications have proven benefits, long-term use raises concerns such as potential impacts on cardiovascular health and growth in children. Several meta-studies and longitudinal studies have been conducted to understand the long-term effects of ADHD medications, particularly focusing on the most commonly used stimulant medications like methylphenidate and amphetamines. 

  • The MTA Study (Multimodal Treatment Study of Children with ADHD):
    • This landmark longitudinal study began in the 1990s and is one of the largest and longest-running investigations into the treatment of ADHD. The study compared the effectiveness of medication management alone, behavioral treatment alone, a combination of both, and standard community care over 14 months initially and has followed up with participants over several years.
    • Initial results suggested that medication management alone, or in combination with behavioral therapy like CBT or ADHD Coaching, was superior to behavioral treatment alone in managing ADHD symptoms. However, longer-term follow-ups indicated that the advantages of early medication treatment diminished over time, suggesting the need for ongoing adjustments and monitoring of treatment strategies.
  • Meta-analyses on the Efficacy and Safety of ADHD Medications:
    • A meta-analysis by the Cochrane Collaboration reviewed studies on methylphenidate for children and adolescents with ADHD and found that while the medication is effective in controlling symptoms, the increase in adverse effects calls for cautious use and close monitoring.
    • Another significant meta-analysis focused on the long-term efficacy and safety of ADHD medications, including amphetamines and methylphenidate, highlighted that while these medications are effective for long-term use, there are potential side effects such as sleep problems and decreased appetite, underscoring the importance of individual assessment and management.
  • Studies on Adult Outcomes:
    • Research looking at the long-term outcomes of individuals who were treated with ADHD medications in childhood often explore various aspects like academic achievement, psychiatric outcomes, substance abuse, and employment status. A general trend noted in these studies is that early and consistent treatment with ADHD medications can lead to better outcomes in adolescence and adulthood.
    • However, there are concerns about the potential for increased risk of cardiovascular issues and the impact on physical growth, though these effects are generally considered to be small or non-significant when medication is properly managed.

Monitoring for Adverse Effects

Regular monitoring by a healthcare professional is crucial to adjust treatment plans as needed and to mitigate any adverse effects from long-term use.

Adjusting ADHD Medication

Importance of Finding the Right Dose

Finding the correct dosage is crucial as too little may be ineffective and too much can cause significant side effects.

Working with a Healthcare Professional

Regular consultations with healthcare providers ensure that treatment remains tailored to individual needs, maximizing benefits while minimizing risks.

These professionals typically include:

  • ✔️Psychiatrists
  • ✔️Pediatricians or Family Medicine Doctors 
  • ✔️Neurologists
  • ✔️Advanced Practice Registered Nurses (APRNs)
  • ✔️Physician Assistants (PAs)

Individualized Treatment Plans

Treatment should be customized based on individual symptoms, responses to previous medications, and other co-existing conditions. Since there are many hidden challenges related to ADHD, it’s important to work with professional to help address the medical, mental, social, and behavioral challnegs. 

Comparing Side Effects Across Different ADHD Medications

ADHD medication side effects comparison

Stimulant vs. Non-Stimulant Medications

Generally, stimulants are associated with more severe side effects, especially concerning cardiovascular issues and potential for abuse, compared to non-stimulants.

Brand-Specific Side Effects

Different formulations and brands of medications can have unique side effects, so closely monitoring symptoms with specific medications is vital.

Factors Influencing Side Effects on Individuals

Genetics, other existing health conditions, and concurrent medications can influence how anindividual responds to ADHD medication. Age, diet, and lifestyle can also affect the occurrence and severity of side effects. Therefore, a collaborative approach involving patients, caregivers, and healthcare providers is essential for optimizing treatment and ensuring safety.

Non-Stimulant Medication

Alternative Options for ADHD Treatment

Non-stimulant medications provide an alternative for those who may not respond well to stimulants or who experience adverse effects. These medications include atomoxetine, guanfacine, and clonidine, which can be particularly useful in treating ADHD symptoms in patients who also have anxiety, as they do not typically provoke the same level of agitation as stimulants.

Benefits and Considerations of Non-Stimulant Medication

Non-stimulant medications often have a slower onset of effect but can be very effective in improving attention, reducing impulsivity, and maintaining a more consistent mood throughout the day without the peaks and troughs sometimes seen with stimulants. They are also less likely to be abused. However, they may take several weeks to establish their full effect.

ADHD Medication in Children

adhd medication side effects for children

Specific Considerations for Children with ADHD

When prescribing medication for children with ADHD, healthcare providers must consider several factors, 

  1. child’s age
  2. potential side effects
  3. possible impact on growth and development.

Age-related Factors

The age of the child influences both the choice of medication and the dosage. Younger children might be more sensitive to certain side effects, and the type of medication chosen can vary based on the child’s ability to tolerate it.

Monitoring Growth and Development

Long-term use of stimulant medications has been associated with a slight reduction in growth rate, although this is not usually clinically significant. Regular monitoring of height and weight is crucial to ensure the child is growing as expected.

Managing ADHD Medication and Mitigating Side Effects

Regular Monitoring by Healthcare Providers

Ongoing assessments are vital to tailor the medication to the patient’s needs, particularly as they grow and their lifestyle or body changes.

Adjusting Medication Dosage or Timing

Dosage adjustments or changes in the timing of medication can help manage or mitigate side effects effectively, ensuring the medication’s benefits outweigh any negatives.

Lifestyle Changes (Diet, Exercise, Sleep Habits)

Dietary adjustments, regular physical activity, and healthy sleep habits can significantly enhance the effectiveness of ADHD medication and reduce side effects.

Behavioral Therapy

Behavioral therapy can be an effective component in managing ADHD, helping to improve conduct and reduce symptoms, often in conjunction with medication.

Executive function coaching for adults or academic coaching for students can be an integral part of an individualized treatment plan for managing ADHD, particularly because it directly addresses the deficits in executive function that are characteristic of the condition. Executive functions include skills such as planning, organization, time management, task initiation, and self-regulation. 

Here’s how executive function coaching can be tailored to fit an individual’s specific needs:

  • 💡 Assessment of Individual Needs
  • 💡 Goal Setting
  • 💡 Developing Strategies and Tools to help regulate focus and attention
    • Time Management: Learning to use planners, calendars, or digital tools to keep track of deadlines and appointments.
    • Task Initiation: Breaking tasks into manageable steps and using techniques like timeboxing to get started.
    • Prioritization: Techniques to identify the most important tasks and focus efforts where they are most needed.
    • Emotional Control: Strategies to manage frustration and anxiety that may arise from tasks or interruptions.
  • 💡 Regular Review and Adjustment
  • 💡 Skill Generalization
  • 💡 Support Systems

Education and Support for Students, Patients and Families

Educating patients and families about ADHD and its treatments can help manage expectations and improve adherence to treatment plans. Both 504 plans and IEPs involve regular meetings between school personnel and the child’s family, creating an ongoing channel of communication that educates parents and guardians about how their child’s needs are being addressed in the school setting. This collaborative approach helps manage expectations and supports adherence to treatment plans by ensuring that both educational strategies and any medical treatments (like ADHD medication) work harmoniously.

504 Plan

A 504 plan is designed to provide support and remove barriers for a student with a disability, such as ADHD, under the Rehabilitation Act of 1973. This plan ensures that a child who has a disability identified under the law and is attending an elementary or secondary educational institution receives accommodations that will ensure their academic success and access to the learning environment.

Examples of accommodations might include:

  • Extended time on tests and assignments.
  • Reduced homework or classwork.
  • Preferential seating.
  • Breaks during class to help with attention.
  • The use of technology to assist in taking notes or completing assignments.

Individualized Education Program (IEP)

An IEP is a more detailed plan provided under the Individuals with Disabilities Education Act (IDEA) that is designed for children who qualify for special education. The IEP includes specific educational goals, is tailored to the child’s individual needs, and often provides more intensive support services than a 504 plan, up unit the child graduates high school.

Components of an IEP for a student with this health-related disability could include:

  • Individualized instruction and interventions specific to the child’s needs.
  • Access to a special education teacher or additional support in the classroom.
  • Academic intervention plans that specify how the school will address behavioral issues that interfere with learning.
  • Regular updates and assessments to ensure goals are being met.

Medication Holidays / Drug Holiday

Taking short breaks from ADHD medication, especially during times when focus demands are lower, such as during school holidays, can reduce side effects and sometimes help to maintain the medication’s effectiveness.

For students, a medication holiday might be during:

During School Breaks: Students may pause their medication during summer or winter breaks when daily demands of schoolwork and the structured environment of school are absent. This can give the body a chance to “reset.”

Weekends: Some families choose to skip medication on weekends if the child’s activities do not require intense concentration or if side effects like reduced appetite are particularly disruptive.

For young adults with ADHD and professionals using medication, the approach might be slightly different:

Vacations: Adults might choose to pause their medication during vacations or other breaks from work to reduce side effects and assess their functioning without medication.

Weekends: Similar to the strategy with students, professionals might opt to not take medication on weekends if their job does not require high focus during these times.

Work from Home Days: On days with a more flexible schedule, such as work-from-home days, adults might skip medication if their day involves less structured tasks.

Alternative or Complementary Therapies

Some patients might find additional benefits from complementary therapies like coaching, mindfulness, yoga, or supplements, although these should never replace conventional treatment without a doctor’s guidance.

  • ADHD coaching involves working with a coach who specializes in ADHD to develop tailored strategies for daily living and tasks. Coaches help clients set realistic goals, manage time and priorities, maintain organization, and work through ADHD-related challenges.
  • Mindfulness-based meditation involves regularly practicing mindfulness exercises to increase attention and reduce hyperactivity.
  • Yoga sessions that focus on both physical postures and breathing techniques can help improve core symptoms of ADHD. Studies have shown that yoga can enhance concentration, reduce hyperactive behavior, and promote calmness. It helps by increasing self-awareness and improving stress management, beneficial for managing ADHD symptoms.
  • Implementing a diet high in protein and balancing complex carbohydrates with healthy fats, while avoiding food colorings and additives often suggested for ADHD.
  • Supplements like fish oil that are rich in EPA and DHA, types of omega-3 fatty acids. Efficacy: Clinical trials indicate that omega-3 supplements can have a modest but positive effect on ADHD symptoms, particularly in improving attention, due to their role in brain function and development.

Importance of Informed Decision-Making

Advice on Side Effect Management

It is crucial for patients and caregivers to understand how to manage side effects effectively. This can range from changing the time medication is taken, to dietary adjustments, or even switching medications.

The Role of Support Systems and Communities

Support groups and communities can provide valuable emotional support and practical advice for managing ADHD, and enhancing the quality of treatment.

Get a Free Screening Call with Dr. David Murphy


ADHD management is a personalized journey, where medication plays a crucial but complex role. Understanding the nuances of different medications and their side effects empowers patients and caregivers to make informed decisions that align with their unique health needs and life circumstances. But remember, you’re not alone in this journey. If you’re seeking further guidance or need personalized advice, don’t hesitate to reach out to us. Schedule a free consultation or contact us today to explore how tailored coaching and support can enhance your or your loved one’s ADHD management strategy. Let us help you turn challenges into stepping stones for success.


Does ADHD medication cause Tics?

Stimulant medications can exacerbate tics in some individuals, although not directly cause them. Non-stimulant medications may be a better option for those with this concern.  The development of tics as a side effect of ADHD medication, particularly stimulants like methylphenidate and amphetamines, is a noted concern but affects a relatively small percentage of patients. The incidence of medication-induced tics is generally reported to be low, with studies suggesting that between about 5% to 10% of children on these medications might experience tics. It’s important to note that tics can be transient and may resolve even with continued medication use.

Are the effects of ADHD medication different on Adults vs Children?

Yes, adults often require different dosages and may experience different side effects than children. Additionally, adults may have more co-existing conditions to consider.  Common side effects in children include decreased appetite, trouble sleeping, headaches, and abdominal pain. Emotional reactions, such as appearing “flat” or less expressive, can also occur. The risk of slowed growth is a unique concern in pediatric patients, requiring regular monitoring. While adults can experience many of the same side effects as children, they may also face different challenges such as increased blood pressure and heart rate, anxiety, and potential interactions with other medications they might be taking for additional health issues.

Is it OK to take a break from ADHD medication?

Yes, under a doctor’s guidance, taking breaks from ADHD medication, known as “drug holidays,” can be beneficial in certain cases to evaluate the need for continuation or adjustment of the medication.

Can children outgrow the need for ADHD medication?

Some children do see a reduction in symptoms as they age and may no longer require medication, but others may continue to benefit from it into adulthood. 

What is the safest medication for ADHD?

The safest ADHD medication varies depending on individual health factors, potential side effects, and the presence of other conditions. This decision should always be made in consultation with a healthcare provider.